Winkler Lab

Royal Institute of Technology (KTH)

Östra Sverige (SE1) · Sweden

ERC-funded
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ERC Starting Grant · 2023

Feedback-control of the Microenvironment: Modular Organ-on-Chip Technology to elucidate the role of Neurovascular Stress in Schizophrenia

A well-controlled microenvironment is paramount for reproducible biomolecular studies. Organs-on-chips are in-vitro cell culture systems that employ microfluidic and biomaterial engineering towards that goal. They combine the advantages of animal models (physiological environment) with those of plastic-dish culture (human cells), and thereby hold exceptional promise in unraveling the biological processes that underlie health and disease. Yet control over the biochemical environment remains poor. With CHIPzophrenia, I propose to develop a new generation of organ-chip, one that features feedback-enabled control of the biochemical environment. I aim to realize dynamic and well-controlled…

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