Tarnaud Lab

Ghent University

Vlaams Gewest (BE2) · Belgium

ERC-funded
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ERC Starting Grant · 2024

Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsy

Epilepsy is a common and debilitating chronic neurological disorder. Furthermore, a large fraction of patients suffers from refractory (drug-resistant) epilepsy. Responsive electrostimulation is a state-of-the-art treatment for refractory epilepsy but is invasive and not cell-type selective. As a result, the surgery is susceptible to complications, e.g., haemorrhage and infection, and overstimulation due to false-positive epilepsy detection can cause brain region overactivity and even induce seizures. In contrast, ultrasound neuromodulation (UNMOD) is a recent, non-invasive and cell-type selective technique, that promises to pave the way for truly inhibitory protocols. The goal of this…

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