Cantini Lab

National Centre for Scientific Research (CNRS)

Ile-de-France (FR1) · France

ERC-funded
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ERC Starting Grant · 2023

Integration of single-cell multi-omics data across space and time to unlock cellular trajectories

The introduction of high-throughput single-cell sequencing has produced a flood of data at the resolution of the single cell, including spatiotemporal information and different molecular facets of a cell, a.k.a. multi-omics. Their integration through MultiModal Learning (MML), aimed at combining multiple complementary views, offers great promise to understand the spatiotemporal phenotypic evolution of a cell and its molecular regulators. However, integrating multi-omics data across space and time is a huge computational challenge requiring radically new MML approaches. MULTIview-CELL will infer multimodal spatiotemporal phenotypic cell trajectories by combining back-translation, to allow…

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