Otto Lab

University of Groningen

Noord-Nederland (NL1) · Netherlands

ERC-funded
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ERC Advanced Grant · 2016

Systems Chemistry: Steps Towards De-Novo Life

Can we synthesise life de-novo in the lab? This is one of the Grand Challenges of contemporary Science. Overall objective of this project is to set important steps in turning chemistry into biology by building fully synthetic chemical systems that contain and integrate some of the essential elements of life: replication, metabolism and compartmentalisation. Functional coupling of any of life’s essential elements has not been achieved, at least not without making use of biomolecules. We now aim to achieve such coupling and develop fully chemical systems to become increasingly life-like. Specific aims are: 1. Achieve and explore Darwinian evolution of a fully synthetic system of peptide-based…

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