ERC Consolidator Grant · 2017
A long standing dogma in the field of cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell spreading, proliferation and fate decision. The use of solid materials to culture adherent cells constitutes an important hurdle for the scale up, automation and speed up of cell culture and recovery. Our recent results show that bulk solid substrates are not necessary to promote cell adhesion, growth and fate regulation as adherent stem cells spread and proliferate readily at the surface of ultra-soft materials, even liquids. In such cases, cell adhesion is enabled by the formation of a mechanically strong layer (nanosheet) of proteins at the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.