Lawrence Lab

University of Edinburgh

- · United Kingdom

ERC-funded
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ERC Starting Grant · 2017

Stereoretentive-Enantioconvergent Catalysis: A New Concept in Asymmetric Synthesis

This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive-enantioconvergent catalysis. This will represent a completely new method for accessing enantiopure materials starting from racemic substrates and will therefore impact all areas of synthetic chemistry. The ability to synthesise chiral molecules in enantiopure form is vitally important, most recognisably for the pharmaceutical industry. This is because the molecules of life are chiral (e.g., D-sugars and L-amino acids) and enantiomers often interact very differently with living organisms. Classically, asymmetric synthesis utilising racemic substrates is limited to achieving a maximum yield of…

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