Phipps Lab

University of Cambridge

- · United Kingdom

ERC-funded
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ERC Starting Grant · 2017

Harnessing Non-Covalent Interactions for Control of Regioselectivity and Site-Selectivity in Catalysis

Nature has been employing attractive non-covalent interactions for billions of years to enable the chemical synthesis machinery of life that is enzymatic catalysis. In comparison, synthetic chemists have only very recently started to employ the very strongest, hydrogen bonds and ion pairs, to control selectivity in synthetic routes. This has occurred predominantly in the rapidly growing of enantioselective organocatalysis and has quickly had a huge impact. The vision of this grant is to take these insights and apply them to control of two more important aspects of selectivity facing the synthetic chemist – regioselectivity (positional selectivity within a particular functional group) and…

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