Brik Lab

Technion - Israel Institute of Technology

- · Israel

ERC-funded
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ERC Advanced Grant · 2018

Delivery and On-Demand Activation of Chemically Synthesized and Uniquely Modified Proteins in Living Cells

While advanced molecular biology approaches provide insight on the role of proteins in cellular processes, their ability to freely modify proteins and control their functions when desired is limited, hindering the achievement of a detailed understanding of the cellular functions of numerous proteins. At the same time, chemical synthesis of proteins allows for unlimited protein design, enabling the preparation of unique protein analogues that are otherwise difficult or impossible to obtain. However, effective methods to introduce these designed proteins into cells are for the most part limited to simple systems. To monitor proteins cellular functions and fates in real time, and in order to…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.

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