ERC Starting Grant · 2018
Sustainable Approach to Drug Discovery
Modern drug discovery is facing critical challenges. Rapid advances in human biology are revealing new biomolecular targets and processes, for which existing chemical compound libraries can provide only limited success in the identification of novel bioactive agents. This deficiency has been attributed primarily to the relative lack of structural diversity within the libraries. The three-dimensional world of biological macromolecules has been continuously interrogated with generally similar planar, aromatic, and structurally simple compounds. Contemporary diversity-generating methods have never been implemented for the preparation of large libraries, as an increase in the number of diverse…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.