ERC Starting Grant · 2018
Reversible Creation of Non-Inherent Reactivity Patterns in Catalytic Organic Synthesis
Current methods in organic synthesis only enable reactions at the most reactive bonds or at bonds predisposed by specific directing groups. Consequently, many less reactive bonds, including numerous C-H and C-C bonds, cannot be functionalized, enormously limiting the scope of possible transformations. To overcome these limitations, I propose Reverse&Cat, a revolutionary strategy using a novel method to change the reactivity pattern of molecules. This strategy combines the dynamic equilibrium mediated by the first catalyst and a functionalization reaction catalyzed by the second catalyst. The originality of the transformation stems from exploiting three simultaneous processes: (i) the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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