ERC Advanced Grant · 2019
Chemical Space for Antimicrobials on a Peptide Basis
Multidrug resistant (MDR) bacteria represent a global public health threat against which new drugs are urgently needed. Antimicrobial peptides (AMPs), mostly derived from naturally occurring linear or cyclic peptides, can contribute to solving the problem. AMPs are already in clinical use, do not easily lead to resistance, and can rely on a strong manufacturing sector and established protocols for clinical development. However, most AMPs are degraded by proteases and have poor pharmacokinetics. SPACE4AMPS aims to identify new AMPs with diverse peptide chain topologies and building blocks and with the following characteristics: i) Broad activity spectrum, ii) High activity, iii) Low…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.