Clayden Lab

University of Bristol

- · United Kingdom

ERC-funded
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Research focus

ERC Advanced Grant · 2019

Artificial Translation with Dynamic Foldamers: Relaying Encoded Messages into Chemical Function

We propose to apply the power of synthetic chemistry to a new challenge in synthetic biomimicry: the translation of encoded information into molecular function. We propose to design and build switchable synthetic molecules that are capable of communicating and processing information. This ambitious aim will be achieved through new classes of extended dynamic molecules that respond to their environment by changing shape, principally by invertase polarity/directionality. They will receive, communicate, amplify, transmit, and process information encoded in their molecular conformation and orientation. New analystic methods will be developed to explore their kinetics and thermodynamics.…

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