ERC Consolidator Grant · 2019
Resurrecting the Carboxyl Polyether Ionophores
The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products. Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure. Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting. Here, I will advocate and demonstrate the opposite position: that not only are these compounds extremely interesting with respect to their complex effects on cells, they also harbor a unique anti-microbial activity that should be a strong priority as we stagger towards a…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.