ERC Consolidator Grant · 2019
New Reagents for Quantifying the Routing and Kinetics of T-cell Activation
The activation of The activation of cytotoxic T-cells (CTLs) marks the key step in the adaptive immune response against cancer and viral infections. Vaccines that activate the CTL-response against tumours are currently hotly pursued, with those targeting tumour-specific mutations now reaching the clinic. However, the capacity of these vaccines to actually activate CTLs is low and rational design improvements are needed to broaden their application. For this, better in vivo knowledge on the processes leading to CTL-activation is needed. CTLs are activated by dendritic cells. These cells take up the vaccine, and process it to 8-10-mer peptides for presentation to CTLs on MHC-I complexes. A…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.