ERC Advanced Grant · 2020
Diadenosine Polyphosphate Alarmones as Drivers for Protein AMPylation
It is puzzling that the human genome has only slightly more genes than the fruit fly and only half the number of cauliflower. Obviously, the sheer number of genes alone cannot determine the complexity of human development and the sophisticated signalling systems that maintain homeostasis. In fact, the complexity of information from genome to proteome is greatly increased. Drivers for the complexity of the proteome are posttranslational modifications (PTMs), i.e. covalent modifications of polypeptides after translation. The aim of this project is to shine light on a scientific mystery known for decades. We will elucidate the cellular roles and functions of diadenosine polyphosphates (ApnAs),…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.