ERC Consolidator Grant · 2020
From Simplicity to Complexity: Crafting Molecular Architectures via Cascade Polyene Cyclizations
Polyene cyclizations belong to the most powerful and fascinating chemical transformations to rapidly assemble molecular architectures. However, the very limited substitution pattern of known substrates and nature’s inability to accommodate heteroatoms or substituents other than methyl restrict molecular diversity, complexity and functionality. CRAFTMOL addresses these limitations by investigating a set of novel heteroatom-substituted and tri/tetrasubstituted polyenes. The participation of these structural units in the cyclization will unlock previously inaccessible reaction pathways and enable efficient, selective and practicable routes to anticancer, anti-inflammatory and antiviral…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.