ERC Advanced Grant · 2021
Random Copolymers Enabling Nonimmunogenic PEGylation for Medical Therapeutics
PEGylation, the attachment of the highly hydrophilic, biocompatible polymer polyethylene glycol (PEG) to therapeutics, has become a key strategy in current nanomedicine. PEGylation is indispensable for a broad variety of commercial therapeutics. They range from protein drugs to relevant nanocarriers, such as liposomes and lipid nanoparticles. PEG leads to the particular “stealth effect”, i.e., strongly prolonged blood circulation times and apparent “invisibility” for the immune system. This is also used for lipid nanoparticles (LNP) transporting mRNA vaccines, used worldwide against the COVID-19 pandemic. However, this powerful weapon is now in danger of becoming blunt: An increasing body…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.