ERC Starting Grant · 2021
Bioorthogonal Cascade-Targeting: Directing Drugs into Cells with Molecular Precision
Bioorthogonal chemistries cross the boundaries between static chemical connectivity and the dynamic physiologic regulation of molecular state, enabling powerful tools for molecular control in complex biological environments. In combination with ligand-directed drug delivery, safe and selective chemical reactions that perform efficiently in vivo can fuel the design of new therapeutic strategies. Despite significant progress in the field of drug targeting, it remains challenging to shuttle therapeutic agents to the desired tissue, reaching the necessary cellular and even sub-cellular level, all while avoiding collateral damage. To engage this challenge, I aim to develop the concept of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.