ERC Advanced Grant · 2022
Breaking resistance of pathogenic bacteria by chemical dysregulation
Antibiotic resistant bacteria are on the rise and could trigger the next global pandemic. For some pathogens no treatment options are left, leading to steadily increasing death tolls. The limited scope of bacterial targets, all essential for growth, has favored resistance build-up whilst also being ineffective against non-growing persister cells. To overcome this threat, innovative concepts are required to effectively and sustainably kill bacteria via unprecedented mechanisms. My team and I tackle this challenge by deliberately going beyond established modes of action (MoA). To achieve this, we present breakingBAC: a three-tiered chemical strategy to dysregulate bacterial physiology. First,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.