Herrmann Lab

DWI – Leibniz Institute for Interactive Materials

Nordrhein-Westfalen (DEA) · Germany

ERC-funded
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ERC Advanced Grant · 2023

Remote controlling biological systems by sonopharmacology and sonogenetics

To date, light has been employed as a widespread trigger to achieve control over the activity of drugs and protein function establishing the fields of photopharmacology and optogenetics, respectively. Both techniques led to promising new therapies, the elucidation of brain function or understanding of neural disorders. However, serious limitations resulting from the low penetration depth of light into tissues are severely hampering progress in these fields. In contrast to photons, ultrasound deeply penetrates tissue and can be applied with sub-millimeter resolution and consequently has been widely established in the clinic over many decades for therapy and diagnostics. In this ERC Advanced…

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