Huskens Lab

University of Twente

Oost-Nederland (NL2) · Netherlands

ERC-funded
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ERC Advanced Grant · 2023

Receptor Recruitment as an Organizational Principle for Self-Assembling Matter

Receptor recruitment occurs in biology as a response to binding, for example, by virus particles to a cell membrane. The interactions that underlie the binding process are typically multivalent in nature, in other words, multiple interactions of the same motif occur simultaneously to provide a collective, cooperative effect. This project aims to employ recruitment as a design criterium for self-assembling building blocks into well-defined architectures. Intrinsically weak and dynamic interactions are essential in achieving self-assembly and recruitment. Exquisite control over stoichiometry and structure of the assemblies is achieved by harnessing ground-breaking developments in the…

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