Melchiorre Lab

University of Bologna

Nord-Est (ITH) · Italy

ERC-funded
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ERC Advanced Grant · 2023

Enhancing the Potential of Enzymatic Catalysis with Light

One pressing challenge of chemical research is to develop new processes that responsibly use natural resources to produce added-value chiral molecules. PHOTOZYME seeks to provide solutions by combining photocatalysis, biocatalysis, and organocatalysis. These three modern strategies offer powerful tools for the sustainable preparation of chiral molecules. To date, however, they have remained largely unconnected. This proposal aims to bridge these fields in order to address major problems in asymmetric synthesis for which there is no general solution with established methods. Specifically, we will focus on native organocatalytic intermediates formed in the enzymes’ active sites, exploring…

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