Tlili Lab

Research focus

ERC Consolidator Grant · 2023

Design of unprecedented electrophilic SF5 reagents: applications in the synthesis of heteroatom-SF5/carbon-SF5 bonds and late-stage functionalization

The Give-Me-Five project will provide the next generation of fluorinated molecules that found plethora of applications in life science. Currently up to 50% of agrochemicals as well as 20% of pharmaceuticals contain a fluorinated motif. As an example, the trifluoromethyl (CF3) group is one of the most used fluorinated motifs in research and development. Although several research programs have been dedicated to the synthesis of CF3-molecules with numerous CF3-reagents being developed, recent reports pointed out a major stability drawback of the CF3 moiety impacting its usefulness. Thus, developing more stable fluorinated motifs that could replace the CF3 group is urgent. In this context,…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.