ERC Consolidator Grant · 2023
A general approach for the design of covalent protein proximity inducers
Chemical biology has made remarkable strides over recent decades, producing potent and selective inhibitors for many proteins, including essential drug targets. Despite these achievements, however, inhibition has been the primary mode of perturbation (GPCRs notwithstanding), whereas many biological processes are controlled through a rich spectrum of biochemical perturbations. What if a small molecule could activate an enzyme? Install or remove a post-translational modification (PTM)? Or control its oligomeric state? The overarching goal of this proposal is to dramatically increase the scope and breadth of perturbations and PTMs one can induce in cells using small molecules. Accomplishing…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.