ERC Starting Grant · 2023
The Journey Matters: Pathway Complexity in Polyplex Formation
A vast number of pathologies have a genetic origin. Yet, using gene therapy to directly intervene at the genetic root remains a rarity within today’s pharmaceutical arsenal. The main hurdles in promoting gene therapy from the lab to the clinic are the complex delivery pathways and biological instability of the therapeutic nucleic acids. Polyplexes, nanoscale coacervates of nucleic acids and (synthetic) polymers, hold the prospect of being highly tunable, scalable and robust transport vehicles and as such a key enabler for gene therapy. Despite years of active research, however, polyplexes have yet to fulfil their claimed potential. Our understanding of polyplex formation and the followed…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.