ERC Starting Grant · 2023
Artificial Catalysts for Endergonic Reduction by Electron Bifurcation
Endergonic catalysis converts low-energy substrates into high-energy products. Such reactions are highly desirable in academia and industry as they allow the transformation of abundant starting materials into complex products. However, endergonic reactions are impossible by classical catalysis, since the reverse reaction to the starting materials always dominates. Nature found an amazing way to drive endergonic reduction reactions catalytically by coupling an energetically uphill reduction to a separate, energetically downhill reduction. This strategy is called electron bifurcation and has been discovered with quinone- and flavin-dependent enzymes. No artificial catalysts capable of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.