Langton Lab

University of Oxford

- · United Kingdom

ERC-funded
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ERC Consolidator Grant · 2024

Artificial molecular machines in membranes: transmembrane relays for ion transport, catalysis and cargo pumping

This program will develop artificial molecular machines confined within lipid bilayer membranes, to control transmembrane transport and catalysis in cellular systems. Molecular machines are ubiquitous in nature. At the heart of many biological processes are protein machines confined within biological membranes, which drive non-equilibrium transmembrane ion pumping via the consumption of chemical fuels. Biology has evolved to utilise the controlled nanomechanical motion of molecular machines to mediate numerous complex tasks in the cellular environment – a clear indication of the immense technological potential of synthetic systems that work in a comparable way. Despite this fundamental…

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