Wallace Lab

University of Edinburgh

- · United Kingdom

ERC-funded
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ERC Consolidator Grant · 2024

New Metabolic Chemistry for Biocompatible Reactions

The field of engineering biology aims to create new metabolic pathways to access chemical products from sustainable feedstocks via fermentation. However, metabolic chemistry is limited to reactions that have evolved in Nature and remains dwarfed by the chemical diversity accessible from petrochemicals by synthetic organic chemists. Urgent solutions must now be sought to bridge this gap and enable the transition of the chemical industry to a more sustainable, climate-positive and net-zero future. Over the past 8 years I have led the emerging field of biocompatible chemistry, which addresses this challenge by interfacing non-enzymatic reactions with metabolism to expand cellular chemistry.…

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