ERC Consolidator Grant · 2024
Chiral bUilding Blocks with bRidged or Caged polyclic structures
“Drug candidates should have a higher proportion of Csp3 over Csp2 and Csp and a greater number of stereogenic centers”. That is essentially the message of F. Lovering et al. in their seminal article “Escape from Flatland” published in 2009 which induced a paradigm change in drug design. The first recommendation (higher proportion of Csp3) has opened a new field of research over the last 15 years, in a quest aiming at the synthesis and functionalization of small rigid polycyclic (bridged or caged) molecular scaffolds, used as building blocks in medicinal chemistry and particularly as bioisosteres of aromatics. This quest has strongly influenced academic and industrial research in organic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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