ERC Starting Grant · 2024
GOLGITACs: Targeted Degradation of Golgi Apparatus residing Carbohydrate Processing Enzymes
Oligosaccharides and glycoconjugates, a hugely diverse claOligosaccharides and glycoconjugates, a hugely diverse class of biomolecules, are closely associated with health and many diseases. Carbohydrate metabolism relies mainly on glycosidases and glycosyltransferases which are carbohydrate processing enzymes (CPEs) that break and create glycosidic bonds, respectively. Controlling their activities is vital for understanding pathological processes in, and developing therapeutics for glycan-related diseases. Recently, new targeted protein degradation (TPD) technologies, which disable disease-related proteins by degradation, have opened possibilities for proteins that are otherwise hard to…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.