ERC Starting Grant · 2024
Catalytic Atroposelective Synthesis for Revealing Elusive Bioactive Conformations and Shapes
Atropisomeric molecules (atropisomers) are separable conformational isomers arising from restricted rotation around a single bond. Atropisomers have revolutionized the treatment of several deadly diseases. The principal goal of AtropShape is to create pharmaceutical leads with unusual conformations and shapes by developing catalytic stereoselective (atroposelective) synthesis methods toward difficult-to-access drug-like atropisomers. Because atropisomers are chiral, they give rise to two or more isomers that have different pharmacological properties. These attributes relate to a crucial, yet minimally investigated and poorly understood fundamental question of how conformational changes,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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