ERC Consolidator Grant · 2025
Mining the ubiquitin system for catalytic activities through advanced ubiquitin probes
I propose a chemoproteomic platform for the discovery of unchartered eraser activities regulating post-translational modifications within the ubiquitin system. This approach will be enabled by a suite of advanced ubiquitin probes. These reagents recapitulate the complexity of cellular polyubiquitin modifications and are equipped with novel electrophilic handles to report on polyubiquitin chain length- and linkage-dependent activities of deubiquitinating enzymes (DUBs). These enzymes reverse ubiquitin modifications and critically determine the outcome of ubiquitin-mediated signalling, yet how they decode ubiquitin chains is largely unclear. Moreover, activity-based probes with novel designs…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.