Greb Lab

University of Heidelberg

Baden-Württemberg (DE1) · Germany

ERC-funded
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ERC Consolidator Grant · 2025

Constraints and Forces for p-Block Element Mediated Bond Activation and Catalysis

Enabling p-block element species for challenging bond activations is crucial for advancing sustainable alternatives to transition metal catalysis. Even more transformative are concepts that guide reactivity in a generalizable manner and for cross-disciplinary impact. While sub-valent species or Frustrated Lewis pairs served as foundational paradigms for p-block-mediated bond activation in recent decades, the structural constraint strategy is emerging as a groundbreaking third approach. However, its fragmented and uncoordinated exploration has limited its broader potential and interdisciplinarity. CONSTRAINOPHORES will consolidate this concept by defining constrainophores ("constrain" +…

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