ERC Consolidator Grant · 2025
Organocatalytic Coordination Microenvironment Design
An overlooked aspect in organocatalyst design relates to nature’s ability to produce a multitude of biochemical products using only a limited number of mechanisms and building blocks. Rather than relying on structural modifications of the catalytically active unit, enzymatic structures primarily vary throughout the coordination microenvironment in which the active unit is embedded. This evolutionary structural principle boosts the number of compounds and reactions that can be efficiently realized by a catalytically active structural motif. In contrast, organocatalysis research has predominantly been focused on systematically modifying catalyst structures while relying on optimization of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.