ERC Starting Grant · 2025
Chemically Tailored Transcription Factor Proteins for Dissecting Gene Expression Regulation
The aberrant function of oncogenic transcription factors (TFs) is one of the most common drivers in human cancers, yet the mechanisms underlying their deregulation and targeting remain elusive. Understanding pathways that regulate TFs function has the potential to develop novel therapeutic compounds to target tumorigenesis. The overreaching goal of ProTailor is to develop ground-breaking modified TFs to understand gene expression regulation mechanisms and set the foundation for therapeutic opportunities to study and target human tumorigenesis. Aim 1: I will develop novel synthetic strategies to prepare site-specifically modified oncogenic TF analogs bearing defined post-translational…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.