Wiesenfeldt Lab

University of Wuppertal

Nordrhein-Westfalen (DEA) · Germany

ERC-funded
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ERC Starting Grant · 2025

ortho-Disubstituted Arenes as Orthogonal Organophotocatalysts for Reduction and Cross-Coupling Reactions

Organocatalytic analogues of transition metal catalysts can future-proof organic synthesis against the depletion of metals, improve the sustainability of chemical production, circumvent catalyst deactivation by Lewis-basic motifs, and avoid toxic metal impurities in drugs. Organocatalytic strategies for the reduction of unactivated C=C bonds and the C–C cross-coupling of unactivated halides, which are among the most common transformations in medicinal chemistry, remain difficult to develop with broad scope as oxidative substrate activation requires highly reactive species. Photocatalysis is a potential solution since it can selectively activate even unreactive motifs under mild conditions.…

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