ERC Advanced Grant · 2017
High-Throughput Cryogenic Spectroscopy for Glycan Analysis
Glycans, or oligosaccharides, are ubiquitous in biological systems. Because they decorate the surface of cells, they play a key role in virtually all cellular recognition processes and are implicated in almost every major disease. Despite their importance, the characterization of glycan primary structure lags far behind that of proteins and DNA because of their intrinsic isomeric complexity. The isomeric nature of the monosaccharide building blocks, the stereochemistry of the glycosidic bond, the possibility of multiple attachment points, and the occurrence of isomeric branched structures all make glycans difficult to analyze. Although mass spectrometry (MS) is one of the most sensitive…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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