ERC Starting Grant · 2017
Visualizing the Conformational Dynamics of Proteins by Time-Resolved Electron Microscopy
The function of many proteins involves large-amplitude domain motions that occur on a timescale of microseconds to millisecond. In the absence of tools to directly observe these dynamics, our understanding of the function of proteins is necessarily incomplete and must frequently rely on extrapolation from known static structures. Here, the implementation of real-time imaging of single particle dynamics in liquid phase is proposed with both microsecond time resolution as well as near-atomic spatial resolution. The experimental approach builds on several recent technological advances, namely the advent of Time-Resolved (“Four-dimensional”) Electron Microscopy, graphene liquid cell technology,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at Swiss Federal Institute of Technology Lausanne (EPFL)