ERC Advanced Grant · 2018
Proteome profiling using plasmonic nanopore sensors
To date, antibody-free protein identification methods have not reached single-molecule precision. Instead, they rely on averaging from many cells, obscuring the details of important biological processes. The ability to identify each individual protein from within a single cell would transform proteomics research and biomedicine. However, single protein identification (ID) presents a major challenge, necessitating a breakthrough in single-molecule sensing technologies. We propose to develop a method for proteome-level analysis, with single protein resolution. Bioinformatics studies show that >99% of human proteins can be uniquely identified by the order in which only three amino-acids,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.