ERC Consolidator Grant · 2020
Analysis of “difficult” proteins by microfluidic-based hydrogen/deuterium exchange
Many proteins important in biology or disease are not amenable to traditional methods for structural analysis as they cannot be isolated in sufficient amounts nor studied directly in their native environment. Alternative techniques are needed to understand the conformation and interactions of such difficult proteins and further support the on-going shift to protein-based ‘biopharmaceuticals’ in the pharmaceutical industry. One promising technique to meet this challenge is the use of mass spectrometry to measure the hydrogen/deuterium exchange of proteins (HDX-MS). However, HDX-MS suffers from significant limitations to realize its full potential and applicability. HDXchip aims to develop…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.