ERC Consolidator Grant · 2020
Digital Protein Biophysics of Aggregation
Proteins are the fundamental building blocks of life, underpinning functional processes in living systems. They are able to exert their biological activities by binding to other proteins to form functional complexes which act as the machinery of life. In certain cases, however, proteins escape cellular quality control mechanisms and form aberrant complexes. The formation of such clusters stabilised by inter-molecular hydrogen bonds, amyloid aggregates, has dramatic consequences for biological systems and they are implicated in neurodegenerative disorders. The fundamental biophysical chemistry governing the formation of protein clusters has been challenging to probe and understand as this…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.