Bucher Lab

Technical University of Munich

Bayern (DE2) · Germany

ERC-funded
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ERC Starting Grant · 2020

Single-cell nuclear magnetic resonance spectroscopy with diamond quantum sensors

Single-cell events are often responsible for biological phenomena, such as drug resistance, cell development or tumorigenesis. Studies on cellular populations mask such characteristics and make single-cell technologies essential for understanding cell biology. However, one of the major analytical tools with the advantage of high molecular specificity and non-invasiveness, nuclear magnetic resonance (NMR) spectroscopy, has been limited in its application to single-cell studies due to its intrinsic low sensitivity. Here, I aim to overcome this limitation by a unique combination of (i) highly sensitive quantum sensors for NMR detection with (ii) microfluidics and (iii) advanced…

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