Glöggler Lab

Max Planck Society

Bayern (DE2) · Germany

ERC-funded
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ERC Starting Grant · 2020

Hyperpolarized ultra-low field (ULF) magnetic resonance to design next generation functional contrast agents

Nuclear magnetic resonance (NMR) is a powerful technique that is widely applied for chemical analysis, structural biology and for medical imaging. Despite its versatility, NMR is inherently insensitive. To overcome sensitivity challenges, hyperpolarization methods were developed that enhance NMR signals by over 10,000-fold. Hyperpolarized molecules have mainly been used in standard high-field imaging as contrast agents to directly observe metabolism. Most of the contrast agents have a traceability of up to 3 minutes until the hyperpolarized signal is depleted, limiting the scope of applications. Contrast agents that are observable for longer time periods (> 10 minutes) hence promise new…

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