ERC Starting Grant · 2021
Revealing cellular behavior with single-cell multi-omics
Chemical reactions govern cellular behavior, and are revealed by analysis of small molecules involved in intracellular metabolism. Individual cells in biological systems continuously adapt to improve survival and biological function, making them chemically and behaviorally heterogeneous. Unraveling this heterogeneity is essential to realize the correlation to disease state and health, but it is masked in bulk analyses of millions of cells. I propose to develop a groundbreaking analytical approach for multi-omics of living individual cells to reveal variability in cellular behavior. This will be achieved by coupling a microfluidic device that enables controlled chemical exposure of a cell,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.