ERC Starting Grant · 2021
BiFoldome: Homo- and Hetero-typic Interactions in Assembled Foldomes
Self-assembly is a fundamental foundation of life, but what about co-assembly? The main goal of BiFOLDOME is to decipher co-assembly to understand self-assembly. Amyloids were assumed to be assembled by one type of protein, but our recent elucidation of the first 1:1 hetero-amyloid structure (the RIPK1-RIPK3 necrosome core) suggests that amyloids composed of two distinct proteins playing key roles in health and disease may be common. In fact, a viral protein (M45) can displace one partner (RIPK1) to form a distinct 1:1 hetero-amyloid (M45-RIPK3). Taking a leaf from the viral playbook, this means that for a given self-assembling sequence there may be a mating sequence driving the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.