ERC Advanced Grant · 2022
A Native Mass Spectrometry Systemic View of Cellular Structural Biology
Protein structure and consequently function is influenced by the cellular content. The array of splice variants, post-translational modifications, cleavages and the ability to bind cofactors and drugs, is governed by the surrounding cellular milieu. This is determined by internal and external cues such as cell type, developmental stage, stress conditions, disease and aging, which give rise to an ensemble of distinct protein entities. To study this diversity, there is a need for methods that enable structural studies under “close-to-life” conditions, maintaining the natural environment and biological diversity, features that are often lost during biochemical purifications. Our recent…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.