Pupeza Lab

Kaiserslautern University of Technology

Rheinland-Pfalz (DEB) · Germany

ERC-funded
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ERC Consolidator Grant · 2022

Laser-Based Infrared Vibrational Electric-Field Fingerprinting

A biological system’s phenotype and the evolution thereof are mirrored in molecular composition. The complexity of biological samples, however, renders quantitative, multivariate molecular probing challenging, in particular for non-destructive, label-free approaches. Vibrational spectroscopies capture signals from all molecular bonds exchanging energy with an optical excitation, delivering highly-specific optical fingerprints of samples in their native state, to which virtually all molecules contribute. Yet, while infrared (IR) spectroscopies profit from large vibrational cross-sections, technical limitations of IR radiation sources and detection have so far limited their applicability to…

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