Bonomi Lab

Research focus

ERC Consolidator Grant · 2022

Integrative, AI-aided Inference of Protein Structure and Dynamics

The life sciences community is living in exciting times. During the past year, Artificial Intelligence (AI), and in particular AlphaFold2, has contributed to advancing our understanding of protein behaviour by enabling structure prediction with accuracy comparable to many experimental techniques at a fraction of their time and costs. However, structures are only a piece of the puzzle. To understand the mechanisms underlying biological functions, we need to characterize the conformational landscape of proteins, the population of relevant states, and their pathways of interconversion. Furthermore, we need to determine the effect of the environment in modulating structures, populations, and…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.