ERC Advanced Grant · 2023
Calcifying Aortic Valve Disease (CAVD) is a cellular-driven disease that actively alters the structure and composition of the valve extracellular matrix, leading to severe disfunction of the heart. Because the molecular mechanisms underlying CAVD are still unknown, there are currently no drug-based therapies and valve replacement is the only available treatment. Specifically, it is still unknown (1) how the disease modifies the extracellular matrix (ECM) to become susceptible for mineralization, (2) how cell differentiation and matrix modification lead to calcification, and (3) how the mineral develops within the matrix. We lack these answers mainly due to our inability to characterize…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.