ERC Consolidator Grant · 2024
Zooming in on small-molecule ligands by magnetic resonance
Small molecules are critical players in the chemistry of life. In the role of substrates, cofactors, solvent, inhibitors or activators, they steer the activities of proteins and nucleic acids. For mechanistic studies, it would be desirable to single out a small ligand from a large macromolecular complex, even if their sizes lie several orders of magnitude apart, and follow its fate during chemical and structural transformations. Few experimental techniques would achieve this under native conditions. NMR spectroscopy grants insights into molecular motions, interactions and chemical transitions at atomic-level resolution. However, it faces challenges when observing small-molecule ligands…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.